Mifepristone also known as RU-486 is a synthetically produced antiprogesterone agent which blocks the progesterone hormone during the early stage of pregnancy. Progesterone is a naturally derived hormone which prepares the lining of the uterus for the implantation of a fertilized egg and helps in maintaining this pregnancy. Without progesterone, the lining of the uterus breaks down, softens and bleeding occurs and so the fertilized egg could not implant in the uterus. Mifepristone also makes the cervix and uterus more sensitive to the effects of Misoprostol. The intake of Mifepristone is usually followed by Misoprostol.
Indications for Mifepristone:
Use Mifepristone as directed by your doctor! Termination of intrauterine pregnancy through 70 days gestation, in a regimen with misoprostol.
Ectopic pregnancy or undiagnosed adnexal mass. IUD in place. Chronic adrenal failure. Prostaglandin allergy. Hemorrhagic disorders. Inherited porphyrias. Concurrent long-term corticosteroid or anticoagulant therapy.
Serious and sometimes fatal infections or bleeding.
Nausea, weakness, fever/chills, vomiting, headache, diarrhea, dizziness; uterine bleeding (may be prolonged or severe), cramping; rare: serious bacterial infections, sepsis (may be fatal).